Crucell Terug naar discussie overzicht

draadje Malaria

1. [verwijderd] 5 december 2006 14:45

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   Is toch van aug. j.l. Flosz?
   
   gr.
   
   Dirk
2. [verwijderd] 5 december 2006 14:50

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   Klopt, zie o.a. pagina 9.
   ...en ook vandaag geen verandering.
   Laatste update is van 24 oktober.
   (ClinicalTrials.gov processed this record on 2006-12-04 ).
   www.clinicaltrials.gov/ct/show/NCT003...
   gr.
3. [verwijderd] 5 december 2006 14:52

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   quote:

   flosz schreef:

   Klopt, zie o.a. pagina 9.
   ...en ook vandaag geen verandering.
   Laatste update is van 24 oktober.
   (ClinicalTrials.gov processed this record on 2006-12-04 ).
   www.clinicaltrials.gov/ct/show/NCT003...
   gr.
   

   Ok thx,
   
   Maar waarom blijft men bij Crucell steeds maar roepen:
   
   "very very shortly" ??
   
   Dirk
4. [verwijderd] 5 december 2006 15:41

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   quote:

   Dirk R. Wijnen schreef:

   "very very shortly" ??
   

   "Je" singalongsong Dirk:
   
   It will come in time, you just be patient
   Everything that's yours will get to you
   Just because some others get theirs early
   Don't you worry, yours is coming too
   
   Tussendoortje:
   Super Blues jam .....
   Met bb, clapton, koko taylor, winwood & Preston( zonder Syreeta).
   
   www.youtube.com/watch?v=pV22m9Dsaa8
5. [verwijderd] 5 december 2006 15:48

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   Next......the thrill is gone???
   
   www.youtube.com/watch?v=RTKd7vSJPk4
6. yinx 6 december 2006 09:47

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   Publicatiedatum: 6-12-2006
   
   'Glaxo veel verder met vaccin dan Crucell'
   SINGAPORE - Het Britse farmaciebedrijf GlaxoSmithKline is 'jaren verder' met de ontwikkeling van een vaccin tegen malaria dan concurrenten als Crucell en Sanofi-aventis. Dat heeft een functionaris van de wereldgezondheidsorganisatie WHO gezegd. Glaxo zou al in 2011 een werkend vaccin kunnen hebben, aldus de WHO. Het Britse bedrijf denkt in 2008 met de laatste testfase voor het middel te kunnen beginnen. (bloomberg)
   
   Copyright (c) 2006 Het Financieele Dagblad
   
   
7. [verwijderd] 6 december 2006 10:50

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   Dit lijkt oud en twijfelachtig nieuws en is vermoedelijk voornamelijk PR, zie opmerkingen in dagdraadje 6/12/6
8. aossa 6 december 2006 11:14

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   Jamaar, je kan je afvragen waarom zo'n PR nu juist moet gedaan worden. Zit er misschien ander nieuws achter de stop van de pipe-line wat GSK niet zo bevalt ?
   
   Crucell: 'malaria nieuws very, very soon, soooon, soo...oon (langzaam uitgalmend).
9. gogogoo 6 december 2006 11:32

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   quote:

   aossa schreef:

   Jamaar, je kan je afvragen waarom zo'n PR nu juist moet gedaan worden. Zit er misschien ander nieuws achter de stop van de pipe-line wat GSK niet zo bevalt ?
   
   Crucell: 'malaria nieuws very, very soon, soooon, soo...oon (langzaam uitgalmend).
   

   Ik speculeer graag met je mee.
10. [verwijderd] 6 december 2006 11:57

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    quote:

    gogogoo schreef:

    Ik speculeer graag met je mee.
    

    Anders ik wel.
    
    {Speculatie} Crucell heeft het voortschrijdend inzicht gekregen, dat, ondanks de uitstekende initiele testresultaten van zijn malaria vaccin kandidaat, het toch de voorkeur verdient voor zo'n grootschalig gebeuren, met jarenlange grootschalige en klinische testen, een samenwerking met een grote pharma te hebben.
    
    Daarom hebben ze nu gesprekken over een nieuwe prime boost strategie met Sanofi. De prime is nu de LSA-3 of MSP-3 peptide van Sanofi (was RTS,S van GSK), en de boost is nog steeds de Ad vector van Crucell. Met Sanofi zijn er uitzichten op een winstdelings-deal (vergelijkbaar met Novartis voor Quinvaxem), wat een grote verbetering is t.o.v de ~ 10% royalty deal waar GSK geen verandering in wilde. {/speculatie}
11. [verwijderd] 6 december 2006 12:00

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    Ik geloof ook wel dat Glaxo verder is. Daarvan zijn al klinische trial data gepubliceerd en van Crucell nog niet. Echter, Crucell heeft waarschijnlijk straks een beter vaccine, dus nog meer patienten worden beschermd.
    Dat is het belangrijkste.
    
    Voor de belegger dus: als je geld aan een malaria vaccine witl verdienen moet je eerst een tijdje in GSK beleggen en dan op tijd switchen naar Crucell.
12. aossa 6 december 2006 12:22

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    Ik wacht nog even af om te switchen want het malaria nieuws vanuit Crucell lijkt dichtbij ;-)
    Als het inderdaad een nieuw contract met Sanofi is, dan hoop ik dat ze tevens het flu-contract hebben herzien ivm exclusiviteit en royalty margin. Misschien dat het daarom even wat langer duurt (speculation).
13. [verwijderd] 11 december 2006 16:09

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    Bill Gates stopt USD 83,5 mln extra in malariabestrijding
    11-12-2006 16:02:26
    
    Amsterdam (NEWS) - Microsoft-oprichter Bill Gates, de rijkste man ter wereld, steekt USD 83,5 miljoen extra in de bestrijding van malaria. Dat is maandag bekendgemaakt.
    
    De Bill & Melinda Gates Foundation, de liefdadigheidsinstelling die Gates midden jaren negentig samen met zijn echtgenote Melinda oprichtte, heeft daarmee tot op heden in totaal USD 765,8 miljoen uitgegeven aan de bestrijding van de ziekte.
    
    Los daarvan heeft de instelling tot op heden USD 650 miljoen toegezegd aan een wereldwijd fonds dat aids, tuberculose en malaria bestrijdt.
    
    De nieuwe toelagen moeten onder andere muskietennetten en behandeling van de ziekte toegankelijker maken. Ook wordt het geld besteed aan versneld onderzoek naar vaccins en nieuwe preventiemethoden.
    
    De aankondiging van de nieuwe toelage komt aan de vooravond van een grote top over malaria in het Amerikaanse Witte Huis op 14 december.
    
    Bij de top, die wordt voorgezeten door president George W. Bush en zijn vrouw Laura, zullen 250 politieke leiders en wetenschappers bij elkaar komen om te praten over nieuwe mogelijkheden om de ziekte wereldwijd te bestrijden.
    
    Ieder jaar worden er 350 miljoen tot 500 miljoen mensen besmet met malaria. Meer dan 1 miljoen van hen overlijdt daadwerkelijk aan het virus. In Afrika sterven er meer kinderen aan malaria dan aan enige andere ziekte.
    
    In de afgelopen twintig jaar is het aantal doden als gevolg van malaria in delen van Afrika verdubbeld, voornamelijk vanwege de toenemende resistentie voor goedkope, veelgebruikte medicijnen.
    
    
14. gogogoo 11 december 2006 16:23

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    Msg: 868 of 868 12/11/2006 10:16:10 AM Recs: 0 Sentiment: Not Disclosed
    By: perseazes Send PM Profile Ignore Recommend Add To Favorites
    Gates Foundation Announces Major Commitment to Global Fight Against Malaria
    
    New grants to expand malaria control, research, and advocacy efforts
    At White House summit, Melinda Gates to call for stronger global malaria
    response, more funding
    
    SEATTLE, Dec. 11 /PRNewswire/ -- On the eve of a major White House
    summit on malaria, the Bill & Melinda Gates Foundation committed $83.5
    million in new grants to combat the disease, which claims more than one
    million lives every year. The grants will expand access to bednets,
    treatment, and other malaria control tools; speed research on vaccines and
    other new prevention methods; and boost global advocacy to fight the
    disease. Melinda Gates, co-chair of the Gates Foundation, will speak at the
    White House summit on December 14.
    "Every day, thousands of mothers watch helplessly as their children die
    from a disease that we have known how to prevent for decades," Mrs. Gates
    said. "The continuing toll of malaria is a moral outrage -- we would not
    allow it here in the U.S., and we should not allow it anywhere."
    "The world is finally waking up to the malaria catastrophe," Mrs. Gates
    continued. "It's time to close the gap in funding, accelerate research, and
    work together in a more strategic way to strengthen the global malaria
    fight."
    The upcoming White House malaria summit, hosted by President Bush and
    First Lady Laura Bush, will convene 250 political leaders, scientists, and
    advocates to discuss new opportunities to combat malaria globally and kick
    off new public-private efforts to address the disease.
    In her remarks, Mrs. Gates will applaud recent increases in funding to
    tackle malaria through efforts like the President's Malaria Initiative, the
    World Bank's Booster Program for Malaria Control, and the Global Fund for
    AIDS, Tuberculosis, and Malaria. However, she will urge world leaders to
    agree on a new, coordinated global strategy to fight malaria. The strategy
    would help maximize the impact of malaria resources by tapping the
    individual strengths of all players in the field, preventing duplication of
    effort, and filling key gaps in global malaria control.
    Mrs. Gates will also call for major new resources for malaria control
    and research. According to the Roll Back Malaria Partnership, global
    spending on malaria control falls far short of the $3.1 billion needed
    annually. Malaria research is also severely under-funded -- a recent study
    by the Malaria R&D Alliance estimated that malaria research funding in 2004
    totaled just $323 million, less than 0.3% of total health research spending
    worldwide.
    New Grants to Expand Malaria Control, R&D Initiatives
    The grants announced today include projects to expand access to
    existing prevention and treatment tools, accelerate research and
    development of new tools, and strengthen global malaria advocacy efforts.
    The grants include:
    * Malaria control: $29 million to the Malaria Control and Evaluation
    Partnership in Africa (MACEPA), based at PATH, to develop a network of
    five African countries committed to fighting malaria. The program will
    support collaboration among developing countries, donors, and other
    public and private partners to rapidly expand and evaluate the
    participating countries' malaria control programs, based on lessons
    learned from MACEPA's work to date in Zambia.
    
    * Vaccine research: $29.3 million to the PATH Malaria Vaccine Initiative
    (MVI) for research on a promising malaria vaccine candidate, and $3.5
    million to the Fraunhofer USA Center for Molecular Biotechnology to
    study potential antigens for use in malaria vaccines. MVI will
    investigate the potential for an attenuated malaria parasite to safely
    protect against malaria infection.
    
    * Preventive treatment for infants: $2.2 million to the World Health
    Organization (WHO) to develop guidelines for intermittent preventive
    treatment for malaria in infants (IPTi), a new strategy to prevent
    severe malaria, and $2.7 million to the Fundacio Clinic per a la Recerca
    Biomedica of the University of Barcelona for research on the
    acceptability and sustainability of IPTi.
    
    * Diagnostics: $9.8 million to the Foundation for Innovative New
    Diagnostics (FIND) to evaluate existing diagnostic tests for malaria,
    and develop guidelines for the effective and efficient use of malaria
    tests in the field.
    
    * Roll Back Malaria Partnership: $7.1 million to the Roll Back Malaria
    Partnership (RBM), based at WHO, to increase technical assistance to
    malaria programs in Southern Africa, and strengthen global advocacy
    activities.
    www.prnewswire.com/cgi-bin/stories.pl...
    Email this page to a friend
    www1.investorvillage.com/smbd.asp?mb=...
15. voda 11 december 2006 17:31

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    Bill Gates steekt extra geld in malariabestrijding
    Microsoftoprichter Bill Gates steekt nog eens 83,5 miljoen dollar in de bestrijding van malaria. Het geld is bestemd voor muskietnetten, het toegankelijker maken van behandelingen en versneld onderzoek naar vaccins en preventiemethoden.
    
    Top
    De Bill en Melinda Gates Foundation, het goede doelen-fonds van de rijkste man ter wereld, heeft daarmee tot op heden 766 miljoen dollar besteed aan malariabestrijding. De nieuwe belofte van Gates’ stichting komt vlak voor een top over malaria in het Witte Huis in Washington op 14 december.
    
    Onder voorzitterschap van president Bush en zijn vrouw zullen 250 politici en wetenschappers praten over bestrijding van de ziekete.
    
    Afrika
    Ieder jaar worden 350 tot 500 miljoen mensen besmet met malaria. Meer dan een miljoen overlijden. In Afrika sterven meer kinderen aan malaria dan aan andere ziektes. De afgelopen 20 jaar is het aantal malariaslachtoffers in delen van Afrika verdubbeld, omdat de ziekte resistent is geworden tegen goedkope veelgebruikte medicijnen.
    Bron: RTLZ
    
    
16. [verwijderd] 11 december 2006 18:29

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    quote:

    gogogoo schreef:

    * Vaccine research: $29.3 million to the PATH Malaria Vaccine Initiative
    (MVI) for research on a promising malaria vaccine candidate, and $3.5
    million to the Fraunhofer USA Center for Molecular Biotechnology to
    study potential antigens for use in malaria vaccines. MVI will
    investigate the potential for an attenuated malaria parasite to safely
    protect against malaria infection.
    

    Partners PATH Malaria Vaccine Initiative
    (MVI):
    
    Bharat Biotech
    The Cooperative Research Centres (CRC)
    GenVec
    GSK
    GroPep
    THE INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
    Kemri
    La Trobe University
    Monash University
    Naval Medical RC (==Verdwenen van de crucell site m.b.t.-anthrax/plague- www.iex.nl/forum/topic.asp?forum=228&... ==)
    
    NIH/NIAID
    The Queensland Institute of Medical Research (QIMR)
    ROYAL BRISBANE HOSPITAL
    USAID
    USAMRU-K
    WRAIR
    MRC Medical Research Council (UK)
    www.malariavaccine.org/ab-current_pro...
    
    Okt. 2005:
    New Gates Funding Will Enable MVI and GSK Biologicals to Complete Development of World’s Most Advanced Malaria Vaccine Candidate
    www.malariavaccine.org/files/BMGF-Ann...
    
    Maart 2006:
    New Agreement Expands Clinical Testing of a Chinese Malaria Vaccine Candidate
    MVI is excited to be a partner in this project and is pleased to support the development of this promising vaccine candidate,” said MVI Director, Dr. Melinda Moree. “Malaria has been killing humans for millennia. The world will need multiple strategies—including a vaccine—to conquer the disease.”
    www.malariavaccine.org/files/060315-W...
    
    Whitehouse-linkje:
    www.whitehouse.gov/infocus/malaria/
    Zie ook pagina 14:
    www.iex.nl/forum/topic.asp?forum=228&...
17. [verwijderd] 11 december 2006 19:20

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    Bill Gates tast opnieuw diep in de buidel voor de bestrijding van malaria. De liefdadigheidsorganisatie van de steenrijke oprichter van Microsoft maakt ruim 63 miljoen euro extra vrij om de infectieziekte te bestrijden. De Bill & Melinda Gates Foundation heeft daarvoor nu in totaal bijna 580 miljoen euro uitgetrokken.
    
    Jaarlijks komen wereldwijd meer dan één miljoen mensen om door malaria. Het geld van Gates moet onder meer muskietennetten en behandeling van de ziekte toegankelijker maken. Ook wordt het geld besteed aan versneld onderzoek naar vaccins en nieuwe preventiemethoden. De aankondiging van de nieuwe donatie komt aan de vooravond van een grote top over malaria in het Amerikaanse Witte Huis op 14 december.
    
    De stichting van Gates is één van de belangrijkste liefdadige instellingen in de wereld. De afgelopen jaren heeft de stichting tientallen miljoenen euro's uitgetrokken voor ontwikkelingsprojecten en medisch onderzoek. (novum)
    
18. ved 11 december 2006 19:48

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    Er doen koortsachtig geruchten de ronde dat Bill Gates etc.......
19. [verwijderd] 11 december 2006 20:23

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    Melinda Gates, Unbound
    
    After Shunning the Limelight,
    She Assumes a More Public Role
    At Her Global Health Foundation
    By MARILYN CHASE
    December 11, 2006; Page B1
    
    After the birth of her first child a decade ago, Melinda Gates, the wife of Microsoft Corp. founder Bill Gates, left her job as a manager at the software giant and devoted her time to caring for their children and quietly guiding strategy for the Bill and Melinda Gates Foundation, the philanthropic powerhouse the couple founded.
    Now that her third child is nearing school age, the 42-year-old Mrs. Gates is stepping into the limelight as an outspoken advocate for closing the global health gap. On Thursday, she plans to announce an expanded initiative with President Bush and first lady Laura Bush's summit on fighting malaria, a mosquito-borne disease that kills one million people a year, mostly children under five.
    
    The Gates Foundation plans to award $83 million in new grants for vaccine research, treatment programs and expansion of its model malaria-control program in Zambia to five more countries. The new grants will bring the foundation's spending on malaria to $765.8 million. The foundation also has given $650 million to the Global Fund to Fight AIDS, Tuberculosis and Malaria, which also finances malaria control.
    The Gateses' new alliance against malaria with the president and first lady -- following a high-profile partnership with former President Bill Clinton -- culminates several years of behind-the-scenes consultation with the Bush White House on its AIDS program. The President's Malaria Initiative, a $1.2 billion effort, aims to cut malaria's death toll in half in 15 countries.
    In excerpts from a wide-ranging interview, Mrs. Gates talks about juggling responsibilities for her young family and the foundation's management of its global health program, brainstorming with her famous husband and stepping out of her previously unseen internal work for the foundation and into the public arena.
    WSJ: How do you, as a woman who is viewed as being reserved, counter the impression that you have been living in Bill's shadow?
    Mrs. Gates: Ha, ha! I think it's really important for people to understand Bill and I are behind this foundation, and it's important for people to understand it's us as a couple. I made a decision a year after our last child, Phoebe, was born, to step out. I was [already] doing a lot of internal strategy work. What was happening, because I had chosen not to step out, was that public thought the foundation was really Bill. It wasn't; it was both of us. Then we did a joint trip to Africa. And slowly but surely as our children got older, I decided to speak out more publicly. Our youngest child is four years old now, and I took some of the time I gave to the foundation internally, and made it external. As all our children start going to school full-time, the time I spend at home reading [about global health] continues to increase. The time I spend at the foundation has continued to increase. As Bill starts to transition in his role at Microsoft, and goes full-time at the foundation, my role will increase in advocacy, in internal work and in trips -- all of which I enjoy doing.
    WSJ: How do you use your own voice for advocacy, and how do you choose the issues and events to focus on?
    Mrs. Gates: It's a work in progress for me. One of the things for Bill and me to constantly remember is that this is a chance for us to shine a light in dark corners of the world with AIDS and malaria. Here's a way forward we see as a couple, and perhaps a way for others to step into gaps. I select where I will step forward and speak according to what issues resonate for me. I spoke at the International AIDS Conference in Toronto because it resonates with me. We both wanted to move the discussion back to prevention. People were working on antiretroviral drugs, and that's wonderful. But if we move away from prevention, it's a disaster.
    I pick things I feel strongly about emotionally and mindfully. A lot of issues around mothers and children resonate strongly. That's why I go to the developing world. I stand back from statistics. To go out to a village and be with a mother and child in a village helps me when I go back to Seattle and choose issues for the foundation to work on.
    WSJ: What strengths do you each bring to this project?
    Mrs. Gates: That's one of the things people misunderstand about Bill and me: We bring a lot of [the same] talents to the foundation. We think, we read an incredible amount, we discuss the issues at home, we go into the field, and it gets ingrained. I got to travel more than Bill in recent years due to Bill's work at Microsoft, and now he's been going out to the developing world. We're both totally passionate.
    WSJ: How are you juggling malaria with other disease priorities -- HIV, tuberculosis, childhood diseases -- these days?
    Mrs. Gates: We're constantly talking about priorities. Bill and I did quite a lot of reading on global health on our recent time off in October. We asked, "How do we make sure we don't spread ourselves too thin?" We wrote an email saying these are our top eight priorities: beginning with HIV, TB, malaria. Under AIDS we culled out separately a microbicide for AIDS. We've got to push on that more than we have been. We develop a portfolio, and make sure we're constantly pushing with the global health team. Sometimes we need to step back and ask, "Have we prioritized enough? Are we focused on what we believe as a couple?"
    WSJ: How do these malaria grants illustrate broader foundation goals and philosophy?
    Mrs. Gates: Bill and I founded the foundation under the premise that all lives have equal value. When we go down the list of diseases, starting with HIV/AIDS, it doesn't take long to find the greatest inequities. Behind AIDS and tuberculosis, it doesn't take you long to get to malaria. As we started to look at malaria from the beginning, it became clear you couldn't focus just on a vaccine. It's the long-term solution. But you also need to work on acute cases of malaria on the ground today, on the things we could get to mothers and children in villages. And how can we use the tools we've got. We began a comprehensive program helping mothers and infants, and controlling malaria in Zambia, and now it's going into five other countries.
    I was in Zambia in March 2006 with the purpose of seeing the program on the ground. When we approved that grant, we said you've got to be kidding. Hasn't somebody tried this? Then we said why has nobody tried it? Are we crazy? You need a government that wants to tackle malaria in such a large-scale way. I was able to see what it takes. It takes the health minister signing up. It takes this enormous effort on the part of government, massive coordination between NGOs [non-governmental organizations] on the ground and new ones coming in. It was fascinating to sit with NGOs and hear about the mistakes they'd made, and about how difficult it was to get [mosquito] nets from point of entry out to the village and the mother. By the time I got there, they'd been talking with each other, and distributing out the work, figuring out how to get trucks there, how to get the nets, breaking the problem down. That was fantastic.
    
20. [verwijderd] 11 december 2006 20:24

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    WSJ: How do you harmonize your projects on malaria with the White House and other partners, rather than having separate malaria projects jostling and competing in the field?
    Mrs. Gates: To be honest, it's a bit like in Zambia. There were already lots of partners on the ground, involving the copper mining industry and others. There was this readiness and willingness to come together, to come to the table. Sometimes it just takes a third party to get people coming together. We were able to get people to the table. The government was huge. As soon as we sat down we were able to share lessons learned, and the pitfalls.
    WSJ: Do the new malaria grants -- in size or timing -- reflect the new money from financier Warren Buffett, which will allow the $31.9 billion Gates Foundation to eventually double its grantmaking?
    Mrs. Gates: With the Warren Buffett money, we can deepen the efforts. Instead of one country, we can work in five. His money lets us expand the global health efforts.
    WSJ: How do you bring other powerful partners on board with your global health agenda, and how does this partnership reflect the way you and Bill are managing the foundation?
    Mrs. Gates: Advocacy is part of this White House summit, making people realize malaria is an issue. When people hear us talk about the Global Fund [to Fight AIDS, Tuberculosis and Malaria], and we've made another substantial grant to Global Fund, it makes people realize their dollars will be effective. When the White House gets involved, they raise awareness. We can say here are some places we've gotten involved and you can step in to the gap.
    In every single thing we do, we say, 'What is our unique role and how do we get others interested and make sure it's ongoing?' It's going to take the involvement of governments. These are enormous, intractable problems. It takes governments.
    online.wsj.com/public/article/SB11658...