Ronn. schreef op 2 maart 2017 16:49:
Gisteren geplaatst op de site van Exas,
www.exactsciences.com/about/latest-ne...MADISON, Wis., March 1, 2017 /PRNewswire/ -- A study from Exact Sciences Corp. (Nasdaq: EXAS) and Mayo Clinic released today by the American Association of Cancer Research (AACR) shows promise for the development of a blood-based lung cancer test. Researchers conducted a multi-round study of nearly 400 patients, which demonstrated high accuracy for detecting lung cancer at all stages.
"These results reveal an opportunity to detect lung cancer from a simple blood draw," said Kevin Conroy, chairman and CEO of Exact Sciences. "Our collaboration with Mayo Clinic is efficiently identifying biomarkers for additional cancer applications on the same technology platform as Cologuard."
AACR released an abstract of the study today, ahead of the presentation of the results on April 2, 2017, during the AACR 2017 annual meeting. The findings from the study of 398 patients (311 controls and 87 cancers) demonstrate that biomarkers in plasma achieved high accuracy for all types and stages of lung cancer. Using two independent regression modeling approaches, a panel of four novel methylated DNA markers demonstrated a sensitivity of 91-96 percent at a specificity of 90-94 percent.
"More studies are needed to corroborate accuracy, however, this plasma DNA test approach appears to be a promising new method and may serve as a rational follow-up to the common findings of lung nodules on CT scanning and may have application in screening for lung cancer," said David E. Midthun, M.D. a pulmonologist at Mayo Clinic.
Exas gebruikt markers van MDxH voor Cologuard, aangezien ze hetzelfde technologie platform gebruiken als Cologuard voor ontwikkeling van de testen voor longkanker zou het interessant om weten zijn of deze markers er ook voor gebruikt worden.